Lipoic acid significantly restores, in rats, the age-related decline in vasomotion

Background and purpose: The age-related decline in vasorelaxation is largely due to ceramide-induced induction of phosphatase 2A (PP2A), which limits nitric oxide synthase (eNOS) phosphorylation at stimulatory sites. We hypothesized that ceramide accumulation was from an age-related loss of endothel...

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Главные авторы: Smith, A R, Visioli, F, Frei, B, Hagen, T M
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2008
Предметы:
Research Papers
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2438266/
https://ncbi.nlm.nih.gov/pubmed/18297110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjp.2008.28
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