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Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking
The protein tyrosine phosphatase Shp2 is a positive regulator of growth factor signaling. Gain-of-function mutations in several types of leukemia define Shp2 as a bona fide oncogene. We performed a high-throughput in silico screen for small-molecular-weight compounds that bind the catalytic site of...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2438240/ https://ncbi.nlm.nih.gov/pubmed/18480264 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0710468105 |
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