Prediction of the tissue-specificity of selective estrogen receptor modulators by using a single biochemical method

Here, we demonstrate that a single biochemical assay is able to predict the tissue-selective pharmacology of an array of selective estrogen receptor modulators (SERMs). We describe an approach to classify estrogen receptor (ER) modulators based on dynamics of the receptor-ligand complex as probed wi...

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Detalhes bibliográficos
Main Authors: Dai, Susie Y., Chalmers, Michael J., Bruning, John, Bramlett, Kelli S., Osborne, Harold E., Montrose-Rafizadeh, Chahrzad, Barr, Robert J., Wang, Yong, Wang, Minmin, Burris, Thomas P., Dodge, Jeffrey A., Griffin, Patrick R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2438222/
https://ncbi.nlm.nih.gov/pubmed/18474858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0710802105
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