Myeloma-derived Dickkopf-1 disrupts Wnt-regulated osteoprotegerin and RANKL production by osteoblasts: a potential mechanism underlying osteolytic bone lesions in multiple myeloma

Multiple myeloma (MM) is characterized by osteolytic bone lesions (OBL) that arise as a consequence of osteoblast inactivation and osteoclast activation adjacent to tumor foci within bone. Wnt signaling in osteoblasts regulates osteoclastogenesis through the differential activation and inactivation...

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Autori principali: Qiang, Ya-Wei, Chen, Yu, Stephens, Owen, Brown, Nathan, Chen, Bangzheng, Epstein, Joshua, Barlogie, Bart, Shaughnessy, John D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2008
Soggetti:
Neoplasia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2435688/
https://ncbi.nlm.nih.gov/pubmed/18305214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-01-132134
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