Enhancement of Poly(orthoester) Microspheres for DNA Vaccine Delivery by Blending with Poly(ethylenimine)

Poly(ortho ester) (POE) microspheres have been previously shown to possess certain advantages for the in vivo delivery of DNA vaccines. In particular, timing of DNA release from POE microspheres in response to acidic phagosomal pH was shown to be an important factor in determining immunogenicity, wh...

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Bibliographische Detailangaben
Hauptverfasser: Nguyen, David N., Raghavan, Shyam S., Tashima, Lauren M., Lin, Elizabeth C., Fredette, Stephen J., Langer, Robert S., Wang, Chun
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2435500/
https://ncbi.nlm.nih.gov/pubmed/18400294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2008.03.01
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