Suppression of sphingomyelin synthase 1 by small interference RNA is associated with enhanced ceramide production and apoptosis after photodamage

We have shown that overexpression of SMS1, an enzyme that converts de novo ceramide into sphingomyelin, is accompanied by attenuated ceramide response and apoptotic resistance after photodamage with the photosensitizer Pc 4 (photodynamic therapy; PDT). To test whether SMS1 overexpression-related eff...

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Bibliografiske detaljer
Main Authors: Separovic, Duska, Semaan, Louie, Tarca, Adi L., Maitah, Ma’In Yehya Awad, Hanada, Kentaro, Bielawski, Jacek, Villani, Maristella, Luberto, Chiara
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2435185/
https://ncbi.nlm.nih.gov/pubmed/18374917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexcr.2008.02.008
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