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Pre-Steady-State Binding of Damaged DNA by XPC–hHR23B Reveals a Kinetic Mechanism for Damage Discrimination
The XPC–hHR23B complex (XPC–hHR23B) is a heterodimeric protein required for the initial step of DNA damage recognition in the global nucleotide excision repair (NER) pathway. A strong preference of XPC–hHR23B for UV- and cisplatin-damaged DNA has previously been demonstrated using equilibrium bindin...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2435173/ https://ncbi.nlm.nih.gov/pubmed/16460043 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi05196t |
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