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Defining how ubiquitin receptors hHR23a and S5a bind polyubiquitin
Ubiquitin receptors connect substrate ubiquitylation to proteasomal degradation. HHR23a binds proteasome subunit 5a (S5a) through a surface that also binds ubiquitin. We report that S5a's UIM2 binds preferentially to hHR23a over polyubiquitin and provide a model for the ternary complex, which w...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3864866/ https://ncbi.nlm.nih.gov/pubmed/17408689 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2007.03.008 |
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