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A transient expansion of the native state precedes aggregation of recombinant human interferon-γ

Aggregation of proteins, even under conditions favoring the native state, is a ubiquitous problem in biotechnology and biomedical engineering. Providing a mechanistic basis for the pathways that lead to aggregation should allow development of rational approaches for its prevention. We have chosen re...

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Detalhes bibliográficos
Main Authors: Kendrick, Brent S., Carpenter, John F., Cleland, Jeffrey L., Randolph, Theodore W.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 1998
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC24340/
https://ncbi.nlm.nih.gov/pubmed/9826667
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