A transient expansion of the native state precedes aggregation of recombinant human interferon-γ

Aggregation of proteins, even under conditions favoring the native state, is a ubiquitous problem in biotechnology and biomedical engineering. Providing a mechanistic basis for the pathways that lead to aggregation should allow development of rational approaches for its prevention. We have chosen re...

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Библиографические подробности

Опубликовано в::	Proc Natl Acad Sci U S A
Главные авторы:	Kendrick, Brent S., Carpenter, John F., Cleland, Jeffrey L., Randolph, Theodore W.
Формат:	Artigo
Язык:	Inglês
Опубликовано:	National Academy of Sciences 1998
Предметы:	Biological Sciences
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24340/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9826667/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.24.14142
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