Adaptor Protein Sorting Nexin 17 Regulates Amyloid Precursor Protein Trafficking and Processing in the Early Endosomes

Accumulation of extracellular amyloid β peptide (Aβ), generated from amyloid precursor protein (APP) processing by β- and γ-secretases, is toxic to neurons and is central to the pathogenesis of Alzheimer disease. Production of Aβ from APP is greatly affected by the subcellular localization and traff...

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Hlavní autoři: Lee, Jiyeon, Retamal, Claudio, Cuitiño, Loreto, Caruano-Yzermans, Amy, Shin, Jung-Eun, van Kerkhof, Peter, Marzolo, Maria-Paz, Bu, Guojun
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2008
Témata:
Molecular Basis of Cell and Developmental Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2431074/
https://ncbi.nlm.nih.gov/pubmed/18276590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800642200
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