HIV-1 Nef Binds PACS-2 to Assemble a Multikinase Cascade That Triggers Major Histocompatibility Complex Class I (MHC-I) Down-regulation: ANALYSIS USING SHORT INTERFERING RNA AND KNOCK-OUT MICE

Human immunodeficiency virus, type 1, negative factor (Nef) initiates down-regulation of cell-surface major histocompatibility complex-I (MHC-I) by assembling an Src family kinase (SFK)-ZAP70/Syk-phosphoinositide 3-kinase (PI3K) cascade through the sequential actions of two sites, Nef EEEE(65) and P...

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Detalhes bibliográficos
Main Authors: Atkins, Katelyn M., Thomas, Laurel, Youker, Robert T., Harriff, Melanie J., Pissani, Franco, You, Huihong, Thomas, Gary
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Membrane Transport, Structure, Function, and Biogenesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2431057/
https://ncbi.nlm.nih.gov/pubmed/18296443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M707572200
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