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Characterization of abasic endonuclease activity of human Ape1 on alternative substrates, as well as effects of ATP and sequence context on AP site incision

Human Ape1 is a multifunctional protein with a major role in initiating repair of apurinic/apyrimidinic (AP) sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage. Besides in double-stranded DNA, Ape1 has been shown to cleave at AP sites in...

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Hlavní autoři: Berquist, Brian R., McNeill, Daniel R., Wilson, David M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2430724/
https://ncbi.nlm.nih.gov/pubmed/18439621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.03.053
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