Dystrophin deficient cardiomyopathy in mouse: Expression of Nox4 and Lox are associated with fibrosis and altered functional parameters in the heart

Duchenne muscular dystrophy (DMD; dystrophin-deficiency) causes dilated cardiomyopathy in the second decade of life in affected males. We studied the dystrophin-deficient mouse heart (mdx) using high frequency echocardiography, histomorphometry, and gene expression profiling. Heart dysfunction was p...

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Bibliographic Details
Main Authors: Spurney, Christopher F., Knoblach, Susan, Pistilli, Emidio E., Nagaraju, Kanneboyina, Martin, Gerard R., Hoffman, Eric P.
Format: Artigo
Language:Inglês
Published: 2008
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2430663/
https://ncbi.nlm.nih.gov/pubmed/18440230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nmd.2008.03.008
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