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Mechanisms of Chemoresistance in Malignant Glioma

Intrinsic or acquired chemoresistance is a major cause of treatment failure in patients with malignant brain tumors. Alkylating agents, the mainstay of treatment for brain tumors, damage the DNA and induce apoptosis, but the cytotoxic activity of these agents is dependent on DNA repair pathways. For...

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Detalhes bibliográficos
Main Authors: Sarkaria, Jann N., Kitange, Gaspar J., James, C. David, Plummer, Ruth, Calvert, Hilary, Weller, Michael, Wick, Wolfgang
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2430468/
https://ncbi.nlm.nih.gov/pubmed/18483356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-07-1719
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