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Characterization of endogenous human Argonautes and their miRNA partners in RNA silencing
Small RNAs triggering RNA silencing are loaded onto Argonautes and then sequence-specifically guide them to target transcripts. Epitope-tagged human Argonautes (hAgo1, hAgo2, hAgo3, and hAgo4) are associated with siRNAs and miRNAs, but only epitope-tagged hAgo2 has been shown to have Slicer activity...
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| Main Authors: | , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2008
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2430345/ https://ncbi.nlm.nih.gov/pubmed/18524951 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0800334105 |
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