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Characterization of endogenous human Argonautes and their miRNA partners in RNA silencing

Small RNAs triggering RNA silencing are loaded onto Argonautes and then sequence-specifically guide them to target transcripts. Epitope-tagged human Argonautes (hAgo1, hAgo2, hAgo3, and hAgo4) are associated with siRNAs and miRNAs, but only epitope-tagged hAgo2 has been shown to have Slicer activity...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Azuma-Mukai, Asuka, Oguri, Hideo, Mituyama, Toutai, Qian, Zhi Rong, Asai, Kiyoshi, Siomi, Haruhiko, Siomi, Mikiko C.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2008
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2430345/
https://ncbi.nlm.nih.gov/pubmed/18524951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0800334105
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