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Role of X11 and ubiquilin as In Vivo Regulators of the Amyloid Precursor Protein in Drosophila
The Amyloid Precursor Protein (APP) undergoes sequential proteolytic cleavages through the action of β- and γ-secretase, which result in the generation of toxic β-amyloid (Aβ) peptides and a C-terminal fragment consisting of the intracellular domain of APP (AICD). Mutations leading to increased APP...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2429963/ https://ncbi.nlm.nih.gov/pubmed/18575606 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0002495 |
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