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Relationships between the structure of organophosphorus compounds and their activity as acetylcholinesterase inhibitors

This paper discusses the relation between chemical structure and inactivation of the enzyme acetylcholinesterase (AChE) by organophosphorus esters, in terms of reactivity and steric effects. The discussion is centered in organophosphorus esters of the type (R) (R′) P(O) X, where X is a readily displ...

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Dettagli Bibliografici
Autore principale: Fukuto, T. R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1971
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2428053/
https://ncbi.nlm.nih.gov/pubmed/5315349
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