Structure of α-Helical Membrane-bound Human Islet Amyloid Polypeptide and Its Implications for Membrane-mediated Misfolding

Human islet amyloid polypeptide (hIAPP) misfolding is thought to play an important role in the pathogenesis of type II diabetes mellitus. It has recently been shown that membranes can catalyze the misfolding of hIAPP via an α-helical intermediate of unknown structure. To better understand the mechan...

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Bibliographic Details
Main Authors: Apostolidou, Melania, Jayasinghe, Sajith A., Langen, Ralf
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2008
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2427348/
https://ncbi.nlm.nih.gov/pubmed/18442979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801383200
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