Phosphorylation of Protein Kinase Cδ on Distinct Tyrosine Residues Induces Sustained Activation of Erk1/2 via Down-regulation of MKP-1: ROLE IN THE APOPTOTIC EFFECT OF ETOPOSIDE

The mechanism underlying the important role of protein kinase Cδ (PKCδ) in the apoptotic effect of etoposide in glioma cells is incompletely understood. Here, we examined the role of PKCδ in the activation of Erk1/2 by etoposide. We found that etoposide induced persistent activation of Erk1/2 and nu...

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Detalhes bibliográficos
Main Authors: Lomonaco, Stephanie L., Kahana, Sarit, Blass, Michal, Brody, Yehuda, Okhrimenko, Hana, Xiang, Cunli, Finniss, Susan, Blumberg, Peter M., Lee, Hae-Kyung, Brodie, Chaya
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2427347/
https://ncbi.nlm.nih.gov/pubmed/18434324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801727200
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