Downregulation of AMP-activated protein kinase by Cidea-mediated ubiquitination and degradation in brown adipose tissue

We previously showed that Cidea(−/−) mice are resistant to diet-induced obesity through the upregulation of energy expenditure. The AMP-activated protein kinase (AMPK), consisting of catalytic α subunit and regulatory subunits β and γ, has a pivotal function in energy homoeostasis. We show here that...

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Hlavní autoři: Qi, Jingzong, Gong, Jingyi, Zhao, Tongjin, Zhao, Jie, Lam, Penny, Ye, Jing, Li, John Zhong, Wu, Jiawei, Zhou, Hai-Meng, Li, Peng
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2008
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2426729/
https://ncbi.nlm.nih.gov/pubmed/18480843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.92
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