Base excision repair deficient mice lacking the Aag alkyladenine DNA glycosylase

3-methyladenine (3MeA) DNA glycosylases remove 3MeAs from alkylated DNA to initiate the base excision repair pathway. Here we report the generation of mice deficient in the 3MeA DNA glycosylase encoded by the Aag (Mpg) gene. Alkyladenine DNA glycosylase turns out to be the major DNA glycosylase not...

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Autors principals: Engelward, Bevin P., Weeda, Geert, Wyatt, Michael D., Broekhof, José L. M., de Wit, Jan, Donker, Ingrid, Allan, James M., Gold, Barry, Hoeijmakers, Jan H. J., Samson, Leona D.
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences of the USA 1997
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC24267/
https://ncbi.nlm.nih.gov/pubmed/9371804
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