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Real-Time Kinetic Modeling of Voltage-Gated Ion Channels Using Dynamic Clamp

We propose what to our knowledge is a new technique for modeling the kinetics of voltage-gated ion channels in a functional context, in neurons or other excitable cells. The principle is to pharmacologically block the studied channel type, and to functionally replace it with dynamic clamp, on the ba...

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Hlavní autoři: Milescu, Lorin S., Yamanishi, Tadashi, Ptak, Krzysztof, Mogri, Murtaza Z., Smith, Jeffrey C.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Biophysical Society 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2426646/
https://ncbi.nlm.nih.gov/pubmed/18375511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.118190
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