Coordinate 5′ and 3′ endonucleolytic trimming of terminally blocked blunt DNA double-strand break ends by Artemis nuclease and DNA-dependent protein kinase

Previous work showed that, in the presence of DNA-dependent protein kinase (DNA-PK), Artemis slowly trims 3′-phosphoglycolate-terminated blunt ends. To examine the trimming reaction in more detail, long internally labeled DNA substrates were treated with Artemis. In the absence of DNA-PK, Artemis ca...

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Detalles Bibliográficos
Main Authors: Yannone, Steven M., Khan, Imran S., Zhou, Rui-Zhe, Zhou, Tong, Valerie, Kristoffer, Povirk, Lawrence F.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2008
Assuntos:
Nucleic Acid Enzymes
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2425473/
https://ncbi.nlm.nih.gov/pubmed/18440975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn205
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