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Role of p53, PUMA, and Bax in wogonin-induced apoptosis in human cancer cells

We observed that treatment of prostate cancer cells for 24 h with wogonin, a naturally occurring monoflavonoid, induced cell death in a dose- and time-dependent manner. Exposure of wogonin to LNCaP cells was associated with increased intracellular levels of p21(Cip-1), p27(Kip-1), p53, and PUMA, oli...

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Autors principals: Lee, Dae-Hee, Kim, Clifford, Zhang, Lin, Lee, Yong J.
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2424318/
https://ncbi.nlm.nih.gov/pubmed/18377871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2008.02.023
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