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Recurrent design patterns in the feedback regulation of the mammalian signalling network

Biochemical networks are characterized by recurrent patterns and motifs, but the design principles underlying the dynamics of the mammalian intracellular signalling network remain unclear. We systematically analysed decay rates of 134 signalling proteins and investigated their gene expression profil...

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Detalhes bibliográficos
Main Authors: Legewie, Stefan, Herzel, Hanspeter, Westerhoff, Hans V, Blüthgen, Nils
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2424294/
https://ncbi.nlm.nih.gov/pubmed/18463614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/msb.2008.29
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