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Synthesis of the ABC Ring System of Azaspiracid. 1. Effect of D Ring Truncation on Bis-spirocyclization

Synthesis of a spirocyclization precursor with a truncated D ring has been accomplished. Subsequent bis-spirocyclization induced the formation of equal amounts of the natural transoidal 10R,13R bis-spirocycle and its cisoidal 10R,13S epimer under an apparent thermodynamically controlled process.

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書目詳細資料
Main Authors: Carter, Rich G., Campbell Bourland, T., Graves, David E.
格式: Artigo
語言:Inglês
出版: 2002
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2424237/
https://ncbi.nlm.nih.gov/pubmed/12074661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol026033w
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