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Identification and Synthesis of a Unique Thiocarbazate Cathepsin L Inhibitor

Library samples containing 2,5-disubstituted oxadiazoles were identified as potent hits in a high throughput screen (HTS) of the NIH Molecular Libraries Small Molecule Repository (MLSMR) directed at discovering inhibitors of cathepsin L. However, when synthesized in pure form, the putative actives w...

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Autors principals: Myers, Michael C., Shah, Parag P., Diamond, Scott L., Huryn, Donna M., Smith, Amos B.
Format: Artigo
Idioma:Inglês
Publicat: 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2423727/
https://ncbi.nlm.nih.gov/pubmed/18060772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2007.10.107
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