Critical Involvement of the ATM-Dependent DNA Damage Response in the Apoptotic Demise of HIV-1-Elicited Syncytia

DNA damage can activate the oncosuppressor protein ataxia telangiectasia mutated (ATM), which phosphorylates the histone H2AX within characteristic DNA damage foci. Here, we show that ATM undergoes an activating phosphorylation in syncytia elicited by the envelope glycoprotein complex (Env) of human...

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Main Authors: Perfettini, Jean-Luc, Nardacci, Roberta, Bourouba, Mehdi, Subra, Frédéric, Gros, Laurent, Séror, Claire, Manic, Gwenola, Rosselli, Filippo, Amendola, Alessandra, Masdehors, Peggy, Chessa, Luciana, Novelli, Giuseppe, Ojcius, David M., Siwicki, Jan Konrad, Chechlinska, Magdalena, Auclair, Christian, Regueiro, José R., de Thé, Hugues, Gougeon, Marie-Lise, Piacentini, Mauro, Kroemer, Guido
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2423469/
https://ncbi.nlm.nih.gov/pubmed/18560558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0002458
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