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Succination of Proteins by Fumarate: Mechanism of Inactivation of Glyceraldehyde-3-Phosphate Dehydrogenase in Diabetes

S-(2-succinyl)cysteine (2SC) is a chemical modification of proteins formed by a Michael addition reaction between the Krebs cycle intermediate, fumarate, and thiol groups in protein—a process known as succination of protein. Succination causes irreversible inactivation of glyceraldehyde-3-phosphate...

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Bibliografiske detaljer
Main Authors: Blatnik, Matthew, Thorpe, Suzanne R., Baynes, John W.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2423376/
https://ncbi.nlm.nih.gov/pubmed/18448829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1196/annals.1433.047
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