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Nischarin Inhibits LIM Kinase To Regulate Cofilin Phosphorylation and Cell Invasion

Nischarin is a novel protein that regulates cell migration by inhibiting p21-activated kinase (PAK). LIM kinase (LIMK) is a downstream effector of PAK, and it is known to play an important role in cell invasion. Here we show that nischarin also associates with LIMK to inhibit LIMK activation, cofili...

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Détails bibliographiques
Auteurs principaux: Ding, Yuemin, Milosavljevic, Tanja, Alahari, Suresh K.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology (ASM) 2008
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2423293/
https://ncbi.nlm.nih.gov/pubmed/18332102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01832-07
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