Histone Deacetylase Inhibitor Depsipeptide Activates Silenced Genes through Decreasing both CpG and H3K9 Methylation on the Promoter

Histone deacetylase inhibitor (HDACi) has been shown to demethylate the mammalian genome, which further strengthens the concept that DNA methylation and histone modifications interact in regulation of gene expression. Here, we report that an HDAC inhibitor, depsipeptide, exhibited significant demeth...

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Main Authors: Wu, Li-Peng, Wang, Xi, Li, Lian, Zhao, Ying, Lu, Shaoli, Yu, Yu, Zhou, Wen, Liu, Xiangyu, Yang, Jing, Zheng, Zhixin, Zhang, Hui, Feng, Jingnan, Yang, Yang, Wang, Haiying, Zhu, Wei-Guo
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2008
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2423178/
https://ncbi.nlm.nih.gov/pubmed/18332107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01516-07
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