Histone Deacetylase Inhibitor Depsipeptide Activates Silenced Genes through Decreasing both CpG and H3K9 Methylation on the Promoter

Histone deacetylase inhibitor (HDACi) has been shown to demethylate the mammalian genome, which further strengthens the concept that DNA methylation and histone modifications interact in regulation of gene expression. Here, we report that an HDAC inhibitor, depsipeptide, exhibited significant demeth...

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Detalhes bibliográficos
Main Authors: Wu, Li-Peng, Wang, Xi, Li, Lian, Zhao, Ying, Lu, Shaoli, Yu, Yu, Zhou, Wen, Liu, Xiangyu, Yang, Jing, Zheng, Zhixin, Zhang, Hui, Feng, Jingnan, Yang, Yang, Wang, Haiying, Zhu, Wei-Guo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2423178/
https://ncbi.nlm.nih.gov/pubmed/18332107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01516-07
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