KSR stimulates Raf-1 activity in a kinase-independent manner

Kinase suppressor of Ras (KSR) is an evolutionarily conserved component of Ras-dependent signaling pathways. Here, we find that murine KSR (mKSR1) translocates from the cytoplasm to the plasma membrane in the presence of activated Ras. At the membrane, mKSR1 modulates Ras signaling by enhancing Raf-...

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出版年:	Proc Natl Acad Sci U S A
主要な著者:	Michaud, Neil R., Therrien, Marc, Cacace, Angela, Edsall, Lisa C., Spiegel, Sarah, Rubin, Gerald M., Morrison, Deborah K.
フォーマット:	Artigo
言語:	Inglês
出版事項:	National Academy of Sciences 1997
主題:	Biological Sciences
オンライン･アクセス:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24217/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9371754/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.24.12792
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