KSR stimulates Raf-1 activity in a kinase-independent manner

Kinase suppressor of Ras (KSR) is an evolutionarily conserved component of Ras-dependent signaling pathways. Here, we find that murine KSR (mKSR1) translocates from the cytoplasm to the plasma membrane in the presence of activated Ras. At the membrane, mKSR1 modulates Ras signaling by enhancing Raf-...

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Detaylı Bibliyografya
Asıl Yazarlar: Michaud, Neil R., Therrien, Marc, Cacace, Angela, Edsall, Lisa C., Spiegel, Sarah, Rubin, Gerald M., Morrison, Deborah K.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The National Academy of Sciences of the USA 1997
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC24217/
https://ncbi.nlm.nih.gov/pubmed/9371754
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