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Pbx1 regulates self-renewal of long-term hematopoietic stem cells by maintaining their quiescence
Self-renewal is a defining characteristic of stem cells, however the molecular pathways underlying its regulation are poorly understood. Here we demonstrate that conditional inactivation of the Pbx1 proto-oncogene in the hematopoietic compartment results in a progressive loss of long-term hematopoie...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2416441/ https://ncbi.nlm.nih.gov/pubmed/18462698 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2008.03.004 |
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