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Pbx1 regulates self-renewal of long-term hematopoietic stem cells by maintaining their quiescence

Self-renewal is a defining characteristic of stem cells, however the molecular pathways underlying its regulation are poorly understood. Here we demonstrate that conditional inactivation of the Pbx1 proto-oncogene in the hematopoietic compartment results in a progressive loss of long-term hematopoie...

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Hlavní autoři: Ficara, Francesca, Murphy, Mark J., Lin, Min, Cleary, Michael L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2416441/
https://ncbi.nlm.nih.gov/pubmed/18462698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2008.03.004
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