Stimulation of CD95 (Fas) blocks T lymphocyte calcium channels through sphingomyelinase and sphingolipids

Calcium influx through store-operated calcium release-activated calcium channels (CRAC) is required for T cell activation, cytokine synthesis, and proliferation. The CD95 (Apo-1/Fas) receptor plays a role in self-tolerance and tumor immune escape, and it mediates apoptosis in activated T cells. In t...

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Detalhes bibliográficos
Main Authors: Lepple-Wienhues, Albrecht, Belka, Claus, Laun, Tilmann, Jekle, Andreas, Walter, Birgit, Wieland, Ulrich, Welz, Martina, Heil, Luzia, Kun, Jutta, Busch, Gillian, Weller, Michael, Bamberg, Michael, Gulbins, Erich, Lang, Florian
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1999
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC24144/
https://ncbi.nlm.nih.gov/pubmed/10570152
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