Stimulation of CD95 (Fas) blocks T lymphocyte calcium channels through sphingomyelinase and sphingolipids

Calcium influx through store-operated calcium release-activated calcium channels (CRAC) is required for T cell activation, cytokine synthesis, and proliferation. The CD95 (Apo-1/Fas) receptor plays a role in self-tolerance and tumor immune escape, and it mediates apoptosis in activated T cells. In t...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Lepple-Wienhues, Albrecht, Belka, Claus, Laun, Tilmann, Jekle, Andreas, Walter, Birgit, Wieland, Ulrich, Welz, Martina, Heil, Luzia, Kun, Jutta, Busch, Gillian, Weller, Michael, Bamberg, Michael, Gulbins, Erich, Lang, Florian
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 1999
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC24144/
https://ncbi.nlm.nih.gov/pubmed/10570152
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы