The transcription factor IFN regulatory factor–4 controls experimental colitis in mice via T cell–derived IL-6

The proinflammatory cytokine IL-6 seems to have an important role in the intestinal inflammation that characterizes inflammatory bowel diseases (IBDs) such as Crohn disease and ulcerative colitis. However, little is known about the molecular mechanisms regulating IL-6 production in IBD. Here, we ass...

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Bibliographic Details
Main Authors: Mudter, Jonas, Amoussina, Lioubov, Schenk, Mirjam, Yu, Jingling, Brüstle, Anne, Weigmann, Benno, Atreya, Raja, Wirtz, Stefan, Becker, Christoph, Hoffman, Arthur, Atreya, Imke, Biesterfeld, Stefan, Galle, Peter R., Lehr, Hans A., Rose-John, Stefan, Mueller, Christoph, Lohoff, Michael, Neurath, Markus F.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2008
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2413182/
https://ncbi.nlm.nih.gov/pubmed/18535667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI33227
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