The transcription factor IFN regulatory factor–4 controls experimental colitis in mice via T cell–derived IL-6

The proinflammatory cytokine IL-6 seems to have an important role in the intestinal inflammation that characterizes inflammatory bowel diseases (IBDs) such as Crohn disease and ulcerative colitis. However, little is known about the molecular mechanisms regulating IL-6 production in IBD. Here, we ass...

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Autori principali: Mudter, Jonas, Amoussina, Lioubov, Schenk, Mirjam, Yu, Jingling, Brüstle, Anne, Weigmann, Benno, Atreya, Raja, Wirtz, Stefan, Becker, Christoph, Hoffman, Arthur, Atreya, Imke, Biesterfeld, Stefan, Galle, Peter R., Lehr, Hans A., Rose-John, Stefan, Mueller, Christoph, Lohoff, Michael, Neurath, Markus F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2008
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2413182/
https://ncbi.nlm.nih.gov/pubmed/18535667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI33227
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