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Cardiomyocyte Expression of a Polyglutamine Pre-amyloid Oligomer Causes Heart Failure

BACKGROUND: To determine if soluble pre-amyloid oligomers (PAOs) are toxic when expressed internally in the cardiomyocyte, we tested the hypothesis that cardiomyocyte-restricted expression and accumulation of a known PAO is cytotoxic and sufficient to cause heart failure. METHODS AND RESULTS: Intrac...

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Detalhes bibliográficos
Main Authors: Pattison, J. Scott, Sanbe, Atsushi, Maloyan, Alina, Osinska, Hanna, Klevitsky, Raisa, Robbins, Jeffrey
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2413062/
https://ncbi.nlm.nih.gov/pubmed/18490523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.107.750232
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