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Mitochondrial Dysfunction and Apoptosis Underlie the Pathogenic Process in Alpha-B-Crystallin Desmin Related Cardiomyopathy
BACKGROUND: Mitochondria and sarcomeres have a well-defined architectural relationship that partially depends upon the integrity of the cytoskeletal network. An R120G missense mutation in the small heat shock protein alpha-B-crystallin (CryAB) causes desmin-related cardiomyopathy (DRM). DRM is chara...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1398051/ https://ncbi.nlm.nih.gov/pubmed/16316967 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.105.572552 |
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