Constitutive expression of an ISGF2/IRF1 transgene leads to interferon-independent activation of interferon-inducible genes and resistance to virus infection.

Interferon (IFN)-stimulated gene factor 2 (ISGF2) plays a role in transcription of the beta IFN (IFN-beta) gene and IFN-stimulated genes (ISGs) and may function as a central mediator of cytokine responses. Constitutive ISGF2 transgene expression resulted in substantial resistance to three RNA virus...

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Detalhes bibliográficos
Publicado no:J Virol
Autor principal: Pine, R
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 1992
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC241256/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1376370/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.66.7.4470-4478.1992
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