ISGF3 with reduced phosphorylation is associated with constitutive expression of interferon-induced genes in aging cells

During cellular aging, many changes in cellular functions occur. A hallmark of aged cells is secretion of inflammatory mediators, which collectively is referred to as the senescence-associated secretory phenotype (SASP). However, the mechanisms underlying such changes are unclear. Canonically, the e...

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Udgivet i:NPJ Aging Mech Dis
Main Authors: Yamagami, Mari, Otsuka, Motoyuki, Kishikawa, Takahiro, Sekiba, Kazuma, Seimiya, Takahiro, Tanaka, Eri, Suzuki, Tatsunori, Ishibashi, Rei, Ohno, Motoko, Koike, Kazuhiko
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237867/
https://ncbi.nlm.nih.gov/pubmed/30455980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41514-018-0030-6
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