Inhibition of HBV Transcription From cccDNA With Nitazoxanide by Targeting the HBx–DDB1 Interaction

BACKGROUND & AIMS: Hepatitis B virus (HBV) infection is a major health concern worldwide. Although currently used nucleos(t)ide analogs efficiently inhibit viral replication, viral proteins transcribed from the episomal viral covalently closed circular DNA (cccDNA) minichromosome continue to be...

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Detalhes bibliográficos
Publicado no:Cell Mol Gastroenterol Hepatol
Main Authors: Sekiba, Kazuma, Otsuka, Motoyuki, Ohno, Motoko, Yamagami, Mari, Kishikawa, Takahiro, Suzuki, Tatsunori, Ishibashi, Rei, Seimiya, Takahiro, Tanaka, Eri, Koike, Kazuhiko
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6357790/
https://ncbi.nlm.nih.gov/pubmed/30704981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2018.10.010
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