Topoisomerase II drives DNA transport by hydrolyzing one ATP

DNA topoisomerase II is a homodimeric molecular machine that couples ATP usage to the transport of one DNA segment through a transient break in another segment. In the presence of a nonhydrolyzable ATP analog, the enzyme is known to promote a single turnover of DNA transport. Current models for the...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Baird, Cheryl L., Harkins, Timothy T., Morris, Shayne K., Lindsley, Janet E.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1999
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24125/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10570133/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.24.13685
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