Mutant p53 can substitute for human papillomavirus type 16 E6 in immortalization of human keratinocytes but does not have E6-associated trans-activation or transforming activity.

Human papillomavirus type 16 (HPV16) E6 and E7 are selectively retained and expressed in HPV16-associated human genital tumors. E6 is active in several cell culture assays, including transformation of NIH 3T3 cells, trans activation of the adenovirus E2 promoter, and cooperation with E7 to immortali...

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Détails bibliographiques

Publié dans:	J Virol
Auteurs principaux:	Sedman, S A, Hubbert, N L, Vass, W C, Lowy, D R, Schiller, J T
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 1992
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC241223/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1318401/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.66.7.4201-4208.1992
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