Mutant p53 can substitute for human papillomavirus type 16 E6 in immortalization of human keratinocytes but does not have E6-associated trans-activation or transforming activity.

Lignende værker

• The full-length E6 protein of human papillomavirus type 16 has transforming and trans-activating activities and cooperates with E7 to immortalize keratinocytes in culture.
  af: Sedman, S A, et al.
  Udgivet: (1991)
• Human papillomavirus type 16 E6 increases the degradation rate of p53 in human keratinocytes.
  af: Hubbert, N L, et al.
  Udgivet: (1992)
• HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes.
  af: Hawley-Nelson, P, et al.
  Udgivet: (1989)
• In vitro biological activities of the E6 and E7 genes vary among human papillomaviruses of different oncogenic potential.
  af: Barbosa, M S, et al.
  Udgivet: (1991)
• Characterization of the human papillomavirus E2 protein: evidence of trans-activation and trans-repression in cervical keratinocytes.
  af: Bouvard, V, et al.
  Udgivet: (1994)