Mutant p53 can substitute for human papillomavirus type 16 E6 in immortalization of human keratinocytes but does not have E6-associated trans-activation or transforming activity.

Human papillomavirus type 16 (HPV16) E6 and E7 are selectively retained and expressed in HPV16-associated human genital tumors. E6 is active in several cell culture assays, including transformation of NIH 3T3 cells, trans activation of the adenovirus E2 promoter, and cooperation with E7 to immortali...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Sedman, S A, Hubbert, N L, Vass, W C, Lowy, D R, Schiller, J T
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 1992
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC241223/
https://ncbi.nlm.nih.gov/pubmed/1318401
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