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A mutation present in the amino terminus of Sabin 3 poliovirus VP1 protein is attenuating.

The attenuated phenotype of Sabin 3 poliovirus compared with its neurovirulent progenitor strain has been largely accounted for by mutations in the genome at positions 472 and 2034 (G. D. Westrop, K. A. Wareham, D. M. A. Evans, G. Dunn, P. D. Minor, D. I. Magrath, F. Taffs, S. Marsden, M. A. Skinner...

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Published in:J Virol
Main Authors: Tatem, J M, Weeks-Levy, C, Georgiu, A, DiMichele, S J, Gorgacz, E J, Racaniello, V R, Cano, F R, Mento, S J
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 1992
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Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC241086/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1313923/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.66.5.3194-3197.1992
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