A mutation present in the amino terminus of Sabin 3 poliovirus VP1 protein is attenuating.

The attenuated phenotype of Sabin 3 poliovirus compared with its neurovirulent progenitor strain has been largely accounted for by mutations in the genome at positions 472 and 2034 (G. D. Westrop, K. A. Wareham, D. M. A. Evans, G. Dunn, P. D. Minor, D. I. Magrath, F. Taffs, S. Marsden, M. A. Skinner...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Tatem, J M, Weeks-Levy, C, Georgiu, A, DiMichele, S J, Gorgacz, E J, Racaniello, V R, Cano, F R, Mento, S J
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1992
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC241086/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1313923/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.66.5.3194-3197.1992
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